Original ArticleElectrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery
Graphical abstract
Controlled release of cisplatin encapsulated in polymeric particles formed via electrohydrodynamic atomization,
a single step process, was utilised to produce cisplatin encapsulated poly (lactic-co-glycolic acid) polymer particles. Control over the size of the particles and loading of cisplatin within the polymeric matrix was facilitated by variation of polymer:drug ratios. The particles were further analysed by SEM-TEM/EDX, FTIR and DSC to confirm the successful encapsulation of cisplatin within the polymeric particles. In order to analyse the mechanism of cisplatin release, in-vitro release tests were performed and it was noted that all the formulations exhibited a two stage release: an initial burst release < 4 h, followed by a sustained release period.
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The authors acknowledge the financial support of the EPSRC (EP/L026287/1 and EP/L025825/1).
Regarding commercial interests and conflict of interest all the authors have nothing to disclose.
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These authors contributed equally to this work.