Review Article
The innovative applications of therapeutic nanostructures in dentistry

https://doi.org/10.1016/j.nano.2017.01.018Get rights and content

Abstract

Nanotechnology has paved multiple ways in preventing, reversing or restoring dental caries which is one of the major health care problems. Nanotechnology aided in processing variety of nanomaterials with innovative dental applications. Some showed antimicrobial effect helping in the preventive stage. Others have remineralizing potential intercepting early lesion progression as nanosized calcium phosphate, carbonate hydroxyapatite nanocrystals, nanoamorphous calcium phosphate and nanoparticulate bioactive glass particularly with provision of self-assembles protein that furnish essential role in biomimetic repair. The unique size of nanomaterials makes them fascinating carriers for dental products. Thus, it is recentlyclaimedthat fortifying the adhesives with nanomaterials that possess biological meritsdoes not only enhance the mechanical and physical properties of the adhesives, but also help to attain and maintain a durable adhesive joint and enhanced longevity. Accordingly, this review will focus on the current status and the future implications of nanotechnology in preventive and adhesive dentistry.

Section snippets

Basic concept of nanotechnology

The matter behaves differently when spectacular elevation occurs in its surface area to volume ratio. Classical physics no longer applied to the behavior of the material which is now under the control of quantum laws. “Quantum theory” represents the basic of modern physics that explains the behavior of matter and energy on atomic and subatomic level. This fact gives the nanostructured material new abilities and properties that may be more favorable than the ones of the bulk material version. A

Generations of nanotechnology development

Mihail Roco of the U.S. National Nanotechnology Initiative has described four generations of nanotechnology development according to increased complexity and dynamics8;

  • 1.

    First generation products/passive nanostructures: are the materials designed to perform one task. Either; dispersed and contact nanostructures as colloids and aerosols or products incorporating nanostructures as coatings, nanoparticles, nanostructured polymers and ceramics.

  • 2.

    Second generation products/active nanostructures: are to

Dimensionality of nanostructures

Nanostructures can be classified on the basis of the grain structure and sizes; they are made up of according to Hu and Shaw,9 into:

  • 1.

    Zero-dimensional (0-D):

The nanostructure has all dimensions in the nanorange. For example: nanoparticles, quantum dots and nanodots.

  • 2.

    One-dimensional (1-D):

One dimension of nanostructure is outside the nanostructure range as nanowires, nanorods and nanotubes.

  • 3.

    Two-dimensional (2-D):

Two dimensions of the nanostructure are outside the nanometer range as coatings and

Nanostructures forms and shapes

Nanostructures come in different forms and shape provided that their dimension located in the range between 0.1 and 100 nm.10They are also of various compositions, thus offer vast variety of modified properties to facilitate innovative applications in dentistry.

Innovative dental applications of nanotechnology in preventive dentistry

The contemporary approaches of modern dentistry relay primary on early prevention of dental caries and minimally invasive approaches. The aid of nanotechnology furnish advanced delineation in the scope of dental caries prevention through fighting microbial biofilm formation and effective remineralization of initial dental decay.47

Dental enamel is considered the furthest mineralized natural tissue. Itis composed of organic and inorganic components, where almost 96 wt.% are inorganic while the

Therapeutic nanoparticles in dental adhesives

Attaining and maintaining a strong and durable adhesive joint between resin composite restorations and enamel and dentin tooth substrates via the use of contemporary adhesive systems is considered a major goal in restorative dentistry. This goal is considered now achieved with the enamel tooth substrate.111, 112, 113 However, the long term durability of the resin–dentin bond hasnot yet been established.54, 114, 115 This could be due to the heterogeneous structure of the dentin substrate,108 to

Nanotoxicity

Nanotoxicity is the expression describing toxicity arising from nanoparticles or nanostructures. According to the principles of toxicology, most of the substances could be considered as potentially toxic to humans. The people at higher risk of exposure to the dental nanomaterials are those at the nanomaterial production site, during research and development staff, as well as the dental staff and patients. In clinical situations, most of the dental nanomaterials were directly applied in the oral

Conclusion

Nanotechnology succeeded to yield strong impact in the dental field. Variety of nanostructures incorporated into the dental materials with innovative applications. Promising advantages of the nanoparticles in dental therapeutics dominate expanded approval particularly in the field of caries prevention, biomimetic repair and dental adhesion of composite restoratives.However, further investigations are required to understand the possible risks, if any, for human health and environment owing to

References (199)

  • E. Viljanen et al.

    Dendritic copolymers and particulate filler composites for dental applications: degree of conversion and thermal properties

    Dent Mater

    (2007)
  • S. Padmanabhan et al.

    Sol–gel synthesis and characterization of hydroxyapatite nanorods

    Particuology

    (2009)
  • M. Sadat-Shojai et al.

    Hydroxyapatite nanorods as novel fillers for improving the properties of dental adhesives: synthesis and application

    Dent Mater

    (2010)
  • T. Kim et al.

    Therapeutic foam scaffolds incorporating biopolymer-shelled mesoporous nanospheres with growth factors

    Acta Biomater

    (2014)
  • L. Chen et al.

    BisGMA/TEGDMA dental composite containing high aspect-ratio hydroxyapatite nanofibers

    Dent Mater

    (2011)
  • S. Lin et al.

    Electrospun nanofiber reinforced and toughened composites through in situ nano-interface formation

    Compos Sci Technol

    (2008)
  • W. Sun et al.

    Post-draw PAN-PMMA nanofiber reinforced and toughened Bis-GMA dental restorative composite

    Dent Mater

    (2010)
  • G. Guo et al.

    Novel dental composites reinforced with zirconia–silica ceramic nanofibers

    Dent Mater

    (2012)
  • X. Ouyang et al.

    Synthesis and characterization of triethylene glycol dimethacrylate nanocapsules used in a self-healing bonding resin

    J Dent

    (2011)
  • P. Shen et al.

    Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial

    J Dent

    (2011)
  • J.F. Hernandez-Sierra et al.

    The antimicrobial sensitivity of Streptococcus Mutans to nanoparticles of silver, zinc oxide, and gold

    Nanomedicine

    (2008)
  • F. Martinez-Gutierrez et al.

    Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles

    Nanomedicine

    (2012)
  • L. Sun et al.

    Preparation and properties of Nano-sized calcium fluoride for dental applications

    Dent Mater

    (2008)
  • S. Huang et al.

    Combined effects of nano-hydroxyapatite and Galla chinensis on remineralisation of initial enamel lesion in vitro

    J Dent

    (2010)
  • Z. Huang et al.

    Biological synthesis of tooth enamel instructed by an artificial matrix

    Biomaterials

    (2010)
  • D.W. Elkassas et al.

    Remineralizing efficacy of different calcium-phosphate and fluoride based delivery vehicles on artificial caries like enamel lesions

    J Dent

    (2014)
  • N. Zhang et al.

    Orthodontic cement with protein-repellent and antibacterial properties and the release of calcium and phosphate ions

    J Dent

    (2016)
  • H. Agheli et al.

    Nanostructured biointerfaces

    Mater Sci Eng

    (2006)
  • Y. Fan et al.

    Controlled remineralization of enamel in the presence of amelogenin and fluoride

    Biomaterials

    (2009)
  • P. Rodgers

    Nanoelectronics: single file

    Nat Nanotechnol

    (2006)
  • H. Miyoshi et al.

    Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

    Int J Cancer

    (2007)
  • K. Drexler

    Molecular engineering: an approach to the development of general capabilities for molecular manipulation

    Proc Natl Acad Sci

    (1981)
  • M. Roco

    Nanoscale science and engineering: unifying and transforming tools

    AIChE J

    (2004)
  • E. Hu et al.

    Synthesis and assembly

  • F. Karlsruhe

    Nanostructured materials: basic concepts and microstructure

    Acta Mater

    (2000)
  • K.A. Wepasnick et al.

    Chemical and structural characterization of carbon nanotube surfaces

    Anal Bioanal Chem

    (2010)
  • L.X. Kong et al.

    Nanotechnology and its role in the management of periodontal diseases

    Periodontol 2000

    (2000)
  • D. Astruc et al.

    Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, and nanomedicine

    Chem Rev

    (2010)
  • K. Yamakami et al.

    Sustainable inhibition efficacy of liposome-encapsulated nisin insoluble glucan-biofilm synthesis by Streptococcus Mutans

    Pharm Biol

    (2013)
  • K. Yamakami et al.

    Effect of liposomal phosphatidylcholine acyl chain length on the bactericidal activity of liposomeencapsulated nisin on cariogenic Streptococcus Mutans

    J Dent Health Oral Disord Ther

    (2014)
  • H. Chen et al.

    Synthesis of fluorapatite nanorods and nanowires by direct precipitation from solution

    Cryst Growth Des

    (2006)
  • K. Mizuno et al.

    Antimicrobial photodynamic therapy with functionalized fullerenes: quantitative structure-activity relationships

    J Nanomed Nanotechnol

    (2011)
  • S. Pacor et al.

    Effects of two fullerene derivatives on monocytes and macrophages

    Biomed Res Int

    (2015)
  • R. Sepahvand et al.

    Enhancement in photocatalytic activity by fullerene- zinc oxide nanocomposites

    J Vet Dent

    (2015)
  • N. Bouropoulos et al.

    Analysis of hydroxyapatite surface coverage by amelogenin nanospheres following the Langmuir model for protein adsorption

    Calcif Tissue Int

    (2003)
  • S. Saunders

    Current practicality of nanotechnology in dentistry. Part 1: focus on nanocomposite restoratives and biomemetics

    Clin Cosmet Investig Dent

    (2009)
  • K. Lin et al.

    Synthesis and characterization of nanocomposite powders composed of hydroxyapatite nanoparticles and wollastonite nanowires

    Int J Appl Ceram Tec

    (2010)
  • D. Costa et al.

    One- and three-dimensional growth of hydroxyapatite nanowires during sol–gel–hydrothermal synthesis

    ACS Appl Mater Interfaces

    (2012)
  • J. Bhuvaneswarri et al.

    Future impact of nanotechnology- a review

    Int J Nanotechnol

    (2013)
  • X. Wang et al.

    Facile synthesis of dental enamel-like hydroxyapatite nanorod arrays via hydrothermal transformation of hillebrandite nanobelts

    J Mater Chem B

    (2015)
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    Declaration of conflict of interest: The authors would like to clarify that they did not receive any funding or research grant during any step of this manuscript assembly and there is no financial or personal interest or belief that could affect objectivity of this submission. Additionally, there isnot any prior presentation of this manuscript abstract or any included tables or figures, at any former meeting and is not concurrently under consideration for publication in another journal.

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