| Feature Article |
| Pathology, Neoplasms, Diagnostic Methods, RNAi |
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In vivo tumor imaging using a novel RNAi-based detection mechanism
20 February 2012
Abstract: A new concept of tumor imaging is introduced using a siRNA-based probe that is capable of amplifying a specific endogenous fluorescence emission in cancerous tissue. In previous studies, we ...
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Kayiu Wan,
Bernd Ebert,
Jan Voigt,
Qing Wang,
Yiyang Dai,
Rainer Haag,
Wolfgang Kemmner
et al.
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393-398
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| Review Article |
| Central Nervous System, Disorders, Therapeutics, Diagnostic Methods |
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Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal
05 September 2011
Abstract: The incidence of neurological diseases of unknown etiology is increasing, including well-studied diseases such as Alzhiemer's, Parkinson's, and multiple sclerosis. The blood-brain barrier pr...
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Jagat R. Kanwar,
Xueying Sun,
Vasu Punj,
Bhasker Sriramoju,
Rajiv R. Mohan,
Shu-Feng Zhou,
Ashok Chauhan,
Rupinder K. Kanwar
et al.
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399-414
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| Short Communications |
| Nervous System, Neural Stem Cells, MEMS, PDMS |
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Initial studies of mechanical compression on neurogenesis with neonatal neural stem cells
27 January 2012
Abstract: In this article we demonstrate the effect of mechanical compression on the behavior of cultured neural stem cells using a microelectromechanical system platform. Polydimethylsiloxane (PDMS)-...
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Leyla Esfandiari,
Michelle Paff,
William C. Tang
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415-418
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| Nervous System, Neural Stem Cells, Carbon Nanofiber Electrodes |
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Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function
09 March 2012
Abstract: Neural chips, which are capable of simultaneous multisite neural recording and stimulation, have been used to detect and modulate neural activity for almost thirty years. As neural interface...
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Zhe Yu,
Timothy E. McKnight,
M. Nance Ericson,
Anatoli V. Melechko,
Michael L. Simpson,
Barclay Morrison
et al.
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419-423
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| Endocrine System, Hormone Therapy, Hormones and Antagonists, Dextran, PEG |
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Preparation and characterization of recombinant human growth hormone–Zn2+-dextran nanoparticles using aqueous phase–aqueous phase emulsion
27 February 2012
Abstract: An effective and simple method was developed to prepare spherical and uniform-sized recombinant human growth hormone (rhGH)–Zn2+-dextran nanoparticles (NPs) for a variety of delivery applica...
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Weien Yuan,
Zhenhua Hu,
Jing Su,
Fei Wu,
Zhenguo Liu,
Tuo Jin
et al.
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424-427
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| Dermatology, Vascular Effects, Nanoparticle Biodistribution, Fe2O3, Ag NPs, QD |
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Acute vascular effects of nanoparticle infusion in isolated perfused skin
09 March 2012
Abstract: The majority of studies on the effect of nanomaterials on biological function involves either isolated in vitro cell systems or are concerned with in vivo effects after inhalational or derma...
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Jim E. Riviere,
Teresa L. Leavens,
James D. Brooks,
Nancy A. Monteiro-Riviere
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428-431
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| Research Articles |
| Biochemistry, Cell Biology, Membrane Proteins, Cell Surface Receptors, Biotin-PEG-RGD |
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Cell adhesion and focal contact formation on linear RGD molecular gradients: study of non-linear concentration dependence effects
22 August 2011
Abstract: Cell adhesion onto bioengineered surfaces is affected by a number of variables, including the former substrate derivatization process. In this investigation, we studied the correlation betwe...
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Anna Lagunas,
Jordi Comelles,
Elena Martínez,
Elisabet Prats-Alfonso,
Gerardo A. Acosta,
Fernando Albericio,
Josep Samitier
et al.
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432-439
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| Pharmacology, Drug Delivery, Liposomes, Curcumin, Cyclodextrin, Comparison of Mechanisms |
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Pages |
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Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma
11 August 2011
Abstract: The delivery of curcumin, a broad-spectrum anticancer drug, has been explored in the form of liposomal nanoparticles to treat osteosarcoma (OS). Curcumin is water insoluble and an effective ...
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Santosh S. Dhule,
Patrice Penfornis,
Trivia Frazier,
Ryan Walker,
Joshua Feldman,
Grace Tan,
Jibao He,
Alina Alb,
Vijay John,
Radhika Pochampally
et al.
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440-451
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| Pharmacology, Drug Delivery, Hyperthermia, Toxicity, Stability, SPNCO NPs |
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Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery
11 August 2011
Abstract: Monodispersed, superparamagnetic nickel cobaltite (NCO) nanoparticles were functionalized using mercaptopropionic acid (MPA). MPA conjugates with NCO forming a metal-carboxylate linkage, wit...
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Sangeeta N. Kale,
Anil D. Jadhav,
Seema Verma,
Soumya J. Koppikar,
Ruchika Kaul-Ghanekar,
Sanjay D. Dhole,
Satishchandra B. Ogale
et al.
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452-459
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| Pharmacology, Drug Delivery, Nanocrystals, Polymeric Stabilizers |
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Author(s) |
Pages |
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Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals
11 August 2011
Abstract: In this study, a novel class of stabilizer, cationic polymer, was introduced into the system of nanocrystals. Taking itraconazole as a poorly soluble model drug, the influence of three catio...
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Wei Sun,
Wei Tian,
Yuyang Zhang,
Jianyong He,
Shirui Mao,
Liang Fang
et al.
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460-467
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| Pharmacology, Drug Delivery, Targeting Macrophages, Comparison of Galactosamine to Liposomes |
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Investigations into an alternate approach to target mannose receptors on macrophages using 4-sulfated N-acetyl galactosamine more efficiently in comparison with mannose-decorated liposomes: an application in drug delivery
22 July 2011
Abstract: In this study the potential of 2 different ligands, i.e., palmitoyl mannose (Man-Lip) and 4-SO4GalNAc (Sulf-Lip) to target resident macrophages was investigated after surface decoration of A...
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Deepak Singodia,
Ashwni Verma,
Rahul K. Verma,
Prabhat Ranjan Mishra
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468-477
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| Pharmacology, Dermatologic Agents, Anti-Infective Agents, Toxicology, SSD, Ag NPs |
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Pages |
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Nanoscalic silver possesses broad-spectrum antimicrobial activities and exhibits fewer toxicological side effects than silver sulfadiazine
11 August 2011
Abstract: Silver has been used successfully for decades as an antibacterial agent and has become a standard treatment for burns and bacterial skin infections. Silver-containing creams, particularly si...
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Oliver Brandt,
Michael Mildner,
Alexander E. Egger,
Michael Groessl,
Uwe Rix,
Martin Posch,
Bernhard K. Keppler,
Christian Strupp,
Beat Mueller,
Georg Stingl
et al.
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478-488
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| Pharmacology, Dermatologic Agents, Pharmacotechnical Evaluation of Ethosomes |
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Pages |
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Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation
11 August 2011
Abstract: This project aimed at developing nanovesicles of econazole nitrate (EN) and formulating them as a suitable dermatological gel for improved therapeutic efficacy, better dispersity, and good s...
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Poonam Verma,
Kamla Pathak
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489-496
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| Communicable Diseases, HIV Therapy, Pathogen-Like NPs, pDNA/PEI |
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Pages |
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Structure and biological activity of pathogen-like synthetic nanomedicines
11 August 2011
Abstract: Here we characterize the structure, stability and intracellular mode of action of DermaVir nanomedicine that is under clinical development for the treatment of HIV/AIDS. This nanomedicine co...
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Orsolya Lőrincz,
Enikő R. Tőke,
Eszter Somogyi,
Ferenc Horkay,
Preethi L. Chandran,
Jack F. Douglas,
János Szebeni,
Julianna Lisziewicz
et al.
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497-506
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| Musculoskeletal System, Gene Therapy, Stem Cells, 3D Scaffolds, Pathway |
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Author(s) |
Pages |
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Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells
11 August 2011
Abstract: A critical strategy for tissue engineering is to provide the signals necessary for tissue regeneration by mimicking the tissue microenvironment. In this study, we mimicked (1) the bone chemi...
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ZuFu Lu,
Seyed-Iman Roohani-Esfahani,
Guocheng Wang,
Hala Zreiqat
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507-515
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| Diagnostic Imaging, Biochemistry, Highly Oriented QD Nanoprobes |
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Pages |
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Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes
11 August 2011
Abstract: Common strategy for diagnostics with quantum dots (QDs) utilizes the specificity of monoclonal antibodies (mAbs) for targeting. However QD-mAbs conjugates are not always well-suited for this...
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Alyona Sukhanova,
Klervi Even-Desrumeaux,
Aymric Kisserli,
Thierry Tabary,
Brigitte Reveil,
Jean-Marc Millot,
Patrick Chames,
Daniel Baty,
Mikhail Artemyev,
Vladimir Oleinikov,
Michel Pluot,
Jacques H.M. Cohen,
Igor Nabiev
et al.
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516-525
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| Radiology, Radiotherapy, ROS, TiO2 NPs |
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Pages |
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Nanoparticle augmented radiation treatment decreases cancer cell proliferation
22 August 2011
Abstract: We report significant and controlled cell death using novel x-ray-activatable titania nanoparticles (NPs) doped with lanthanides. Preferential incorporation of such materials into tumor tiss...
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Helen E. Townley,
Elizabeth Rapa,
Gareth Wakefield,
Peter J. Dobson
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526-536
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| Frontmatter |
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Cover 1
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A1
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About the Cover
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A2
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Editorial Board
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A3
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Table of Contents
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A4-A5
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